Macleod K, Leprince D, Stehelin D
CNRS, Institut Pasteur, Lille, France.
Trends Biochem Sci. 1992 Jul;17(7):251-6. doi: 10.1016/0968-0004(92)90404-w.
Ets proteins have a conserved DNA-binding domain and regulate transcriptional initiation from a variety of cellular and viral gene promoter and enhancer elements. Some members of the Ets family, Ets-1 and Ets-2, cooperate in transcription with the AP-1 transcription factor, the product of the proto-oncogene families, fos and jun, while others, Elk-1 and SAP-1, form ternary complexes with the serum response factor (SRF). Certain ets gene family members possess transforming activity while others are activated by proviral integration in erythroleukaemias.
Ets蛋白具有保守的DNA结合结构域，可调控多种细胞和病毒基因启动子及增强子元件的转录起始。Ets家族的一些成员，如Ets-1和Ets-2，与AP-1转录因子（原癌基因家族fos和jun的产物）协同进行转录，而其他成员，如Elk-1和SAP-1，则与血清反应因子（SRF）形成三元复合物。某些ets基因家族成员具有转化活性，而其他成员则在红白血病中被前病毒整合激活。
