[“比纳酶”制剂在沙门氏菌试验中的遗传毒性：艾姆斯试验和ARA试验]
[Genotoxicity of the preparation "binase" in tests on Salmonella: Ames test and ARA-test].
作者信息
Ivanchenko O B, Il'inskaia O N, Karamova N S
出版信息
Tsitol Genet. 1992 May-Jun;26(3):52-6.
PMID:1502733
Abstract
The present work deals with mutagenicity determination of enzyme sample "binase" (Bacillus intermedius ribonuclease) in microbial test-systems: Ames test and Ara-test. The weak mutagenic effect of "binase" high concentration was established in both tests by induction of forward Ara-mutations and Histidine-reverse mutations. A metabolic activation is seen to remove this effect.
摘要
本研究通过微生物测试系统（埃姆斯试验和Ara试验）对酶样品“binase”（中间芽孢杆菌核糖核酸酶）的致突变性进行了测定。在两个试验中，通过诱导正向Ara突变和组氨酸反向突变，均确定了“binase”高浓度具有微弱的致突变作用。代谢激活可消除这种作用。
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