Strieter Robert M, Belperio John A, Phillips Roderick J, Keane Michael P
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, David Geffen School of Medicine, UCLA, 900 Veteran Avenue, 14-154 Warren Hall, Box 711922, Los Angeles, CA 90024-1922, USA.
Novartis Found Symp. 2004;256:173-84; discussion 184-8, 259-69.
Non-small cell lung cancer (NSCLC) growth, angiogenesis, invasion, and metastases to specific organs is dependent on an orchestrated series of events that include: cellular transformation; establishment of a pro-angiogenic environment; tumour cell proliferation, invasion and entry into the circulation; and tumour cell trafficking and metastatic tumour growth in specific organs based on the concept of Paget's theory of 'seed and soil' related to homing of tumour cells to a specific organ. The events that destine a tumour cell to invade and metastasize to distant organs are analogous to leukocyte trafficking. Chemokines have had an increasingly important role in mediating the homing of leukocytes under both conditions of homeostasis and inflammatory/immunological responses. Recently, the biology of chemokines has extended beyond their role in mediating leukocyte trafficking. Specifically, CXC chemokines have been found to be important in the regulation of angiogenesis, and in promoting tumour cell migration and organ-specific metastases. Data will be presented to highlight the importance of CXC chemokine ligands and receptors in mediating NSCLC tumour-associated angiogenesis, 'immunoangiostasis', and organ specific metastases. These findings may ultimately lead to clinical strategies to attenuate the pathobiology of CXC chemokines in promoting NSCLC tumour growth and metastases.
非小细胞肺癌（NSCLC）的生长、血管生成、侵袭以及向特定器官的转移取决于一系列精心编排的事件，这些事件包括：细胞转化；促血管生成环境的建立；肿瘤细胞增殖、侵袭并进入循环系统；以及基于佩吉特“种子与土壤”理论（即肿瘤细胞归巢至特定器官）的肿瘤细胞在特定器官中的运输和转移性肿瘤生长。决定肿瘤细胞侵袭并转移至远处器官的事件类似于白细胞运输。趋化因子在稳态以及炎症/免疫反应条件下介导白细胞归巢过程中发挥着越来越重要的作用。最近，趋化因子的生物学功能已超出其在介导白细胞运输方面的作用。具体而言，已发现CXC趋化因子在血管生成调节以及促进肿瘤细胞迁移和器官特异性转移方面具有重要作用。将展示相关数据以突出CXC趋化因子配体和受体在介导NSCLC肿瘤相关血管生成、“免疫血管稳态”以及器官特异性转移中的重要性。这些发现最终可能会带来临床策略，以减轻CXC趋化因子在促进NSCLC肿瘤生长和转移方面的病理生物学作用。
