Ononiwu I M, Ibeneme C E, Ebong O O
Department of Pharmacology, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria.
Afr J Med Med Sci. 2002 Dec;31(4):293-5.
Piperine, the pungent principle in Piper nigrum and Piper guinensis was studied for its effect on gastric acid secretion in white albino rats. Increasing the dose from 20 mg kg(-1) weight to 142 mg kg(-1) body weight produced dose dependent increases in gastric acid secretion. When compared with control basal acid secretion, these increases were significant (P<0.05). 20 mg kg(-1) produced a 22.2% (n=7) increase, while the highest dose employed in this study (142 mg kg(-1)) produced 334.6% (n=7) increase in the gastric acid secretion. Piperine was however about 40 times less effective than histamine in increasing gastric acid secretion. The effect of piperine was significantly antagonized by cimetidine (1 mg kg(-1), n=6) but not by atropine (1 mg kg(-1), n=6). Any involvement of cholinergic receptors in the observed piperine-induced increase in gastric acid secretion is thus excluded. There is however an indication that stimulation of histamine H2 receptors by piperine is likely to be involved in the increased acidity induced by piperine.
胡椒碱是黑胡椒和几内亚胡椒中的辛辣成分，研究了其对白化大鼠胃酸分泌的影响。将剂量从20毫克/千克体重增加到142毫克/千克体重，胃酸分泌呈剂量依赖性增加。与对照基础胃酸分泌相比，这些增加具有显著性（P<0.05）。20毫克/千克体重导致胃酸分泌增加22.2%（n=7），而本研究中使用的最高剂量（142毫克/千克体重）使胃酸分泌增加334.6%（n=7）。然而，胡椒碱在增加胃酸分泌方面的效力约为组胺的40分之一。西咪替丁（1毫克/千克体重，n=6）可显著拮抗胡椒碱的作用，但阿托品（1毫克/千克体重，n=6）则不能。因此排除了胆碱能受体参与观察到的胡椒碱诱导的胃酸分泌增加的可能性。然而，有迹象表明，胡椒碱对组胺H2受体的刺激可能参与了胡椒碱诱导的酸度增加。
