Mujumdar A M, Dhuley J N, Deshmukh V K, Raman P H, Thorat S L, Naik S R
Laboratory of Pharmacology and Toxicology, Hindustan Antibiotics Ltd, Pimpri, Pune, India.
Indian J Exp Biol. 1990 May;28(5):486-7.
Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.
胡椒碱（1-胡椒酰哌啶）是从胡椒中分离出的一种主要生物碱，它能以剂量依赖的方式延长戊巴比妥睡眠时间，30分钟时达到最大效应。用胡椒碱处理的动物血液和大脑中的戊巴比妥水平较高。与对照组相比，长期用苯巴比妥处理的大鼠再用胡椒碱处理后，戊巴比妥睡眠时间显著延长。巴比妥钠睡眠时间没有变化。胡椒碱可能抑制肝脏微粒体酶系统，从而延长戊巴比妥睡眠时间。
