Salako B L, Ayodele O E, Kadiri S, Arije A
Department of Medicine, University College Hospital, Ibadan, Nigeria.
Afr J Med Med Sci. 2002 Dec;31(4):311-4.
CRF affects people in their prime of life; they are often the Nation's workforces thereby leading to severe economic and social problems. Many patients with CRF who need dialysis, present for the first time in end stage renal failure. The commonest causes of CRF in Nigeria and other tropical countries have been reported to be hypertensive nephrosclerosis and chronic glomerulonephritis. Various studies in and outside Nigeria have documented an increased seroprevalence of anti-HCV and HBsAg in chronic renal failure patients on maintenance haemodialysis. Any association established between these viruses and CRF would suggest that the prevention and/or treatment of these viruses may likely lead to a reduction in the prevalence of CRF. Thus, forty-five (45) consecutive subjects with CRF and (45) age- and sex-matched control subjects who satisfied the eligibility criteria for the study were enrolled. Marker of HBV (HBsAg) was assayed using HUMAN Enzyme linked Immunosorbent Assay (ELISA) Test. Marker of HCV (anti-HCV) was determined using the HUMAN ELISA Test. The mean age of the subjects was 37 +/- 14 years (range 17 to 62 years) while the mean age of the control subjects was 38 +/- 14 years (range of 18 to 66 years). There were no statistically significant differences in the prevalence of HBsAg and anti-HCV in the CRF patients and controls P=0.74 and P=1.0 respectively. Although, the sample was small anti-HCV seropositive CRF patients were significantly younger than anti-HCV seropositive controls P<0.027. In conclusion, this study has shown that there were no significant differences in the prevalences of HBsAg and anti-HCV in the CRF patients and controls. A larger scale study may be more desirable in defining the role of these viruses in patients with chronic renal failure.
慢性肾功能衰竭影响处于人生黄金时期的人群；他们往往是国家的劳动力，从而导致严重的经济和社会问题。许多需要透析的慢性肾功能衰竭患者首次就诊时已处于终末期肾衰竭。据报道，尼日利亚和其他热带国家慢性肾功能衰竭最常见的病因是高血压性肾硬化和慢性肾小球肾炎。尼日利亚国内外的各种研究记录了维持性血液透析的慢性肾衰竭患者中抗丙型肝炎病毒（anti-HCV）和乙型肝炎表面抗原（HBsAg）血清阳性率增加。这些病毒与慢性肾功能衰竭之间建立的任何关联都表明，对这些病毒的预防和/或治疗可能会降低慢性肾功能衰竭的患病率。因此，连续纳入了45名符合研究资格标准的慢性肾功能衰竭受试者以及45名年龄和性别匹配的对照受试者。使用人类酶联免疫吸附测定（ELISA）试验检测HBV标志物（HBsAg）。使用人类ELISA试验测定HCV标志物（anti-HCV）。受试者的平均年龄为37±14岁（范围17至62岁），而对照受试者的平均年龄为38±14岁（范围18至66岁）。慢性肾功能衰竭患者和对照组中HBsAg和anti-HCV的患病率无统计学显著差异，P值分别为0.74和1.0。尽管样本量较小，但抗-HCV血清阳性的慢性肾功能衰竭患者明显比抗-HCV血清阳性的对照者年轻，P<0.027。总之，本研究表明慢性肾功能衰竭患者和对照组中HBsAg和anti-HCV的患病率无显著差异。在确定这些病毒在慢性肾衰竭患者中的作用方面，可能更需要进行大规模研究。
