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2
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Murine scrapie infection causes an abnormal germinal centre reaction in the spleen.鼠类瘙痒病感染会在脾脏中引发异常的生发中心反应。
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Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.补体成分C3的暂时耗竭或C1q的基因缺陷会显著延迟羊瘙痒病的发病。
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In Vitro and In Vivo Evidence towards Fibronectin's Protective Effects against Prion Infection.纤维连接蛋白对朊病毒感染的保护作用的体外和体内证据。
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本文引用的文献

1
Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility.通过用淋巴毒素途径抑制剂处理使滤泡树突状细胞去分化，可显著降低羊瘙痒病易感性。
J Virol. 2003 Jun;77(12):6845-54. doi: 10.1128/jvi.77.12.6845-6854.2003.
2
Occurrence and distribution of infection-specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie-affected farms in Shetland.设得兰群岛临床羊瘙痒病病例及来自瘙痒病感染农场的扑杀绵羊组织中感染特异性朊蛋白的发生与分布
J Comp Pathol. 2002 Nov;127(4):264-73. doi: 10.1053/jcpa.2002.0592.
3
Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry.通过双重标记免疫组织化学对自然感染羊瘙痒病的绵羊淋巴组织和神经组织中积累朊病毒蛋白（PrPsc）的细胞进行表型分析。
J Histochem Cytochem. 2002 Oct;50(10):1357-70. doi: 10.1177/002215540205001009.
4
New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1).
J Gen Virol. 2002 May;83(Pt 5):1247-1250. doi: 10.1099/0022-1317-83-5-1247.
5
Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie.病原体毒株和宿主基因型对自然感染及实验性感染羊瘙痒病的绵羊大脑中朊蛋白积累的影响。
J Comp Pathol. 2002 Jan;126(1):17-29. doi: 10.1053/jcpa.2001.0516.
6
Neuroinvasion by a Creutzfeldt-Jakob disease agent in the absence of B cells and follicular dendritic cells.在缺乏B细胞和滤泡树突状细胞的情况下，克雅氏病病原体的神经侵袭。
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9289-94. doi: 10.1073/pnas.161055198. Epub 2001 Jul 24.
7
Detection of immune system cells in paraffin wax-embedded ovine tissues.石蜡包埋绵羊组织中免疫系统细胞的检测
J Comp Pathol. 2001 Jul;125(1):41-7. doi: 10.1053/jcpa.2001.0475.
8
Complement facilitates early prion pathogenesis.补体促进朊病毒早期发病机制。
Nat Med. 2001 Apr;7(4):488-92. doi: 10.1038/86567.
9
Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.补体成分C3的暂时耗竭或C1q的基因缺陷会显著延迟羊瘙痒病的发病。
Nat Med. 2001 Apr;7(4):485-7. doi: 10.1038/86562.
10
Pathogenesis of natural scrapie in sheep.绵羊自然痒病的发病机制。
Arch Virol Suppl. 2000(16):57-71. doi: 10.1007/978-3-7091-6308-5_5.

实验性感染羊瘙痒病的绵羊次级淋巴组织结构

Architecture of secondary lymphoid tissue in sheep experimentally challenged with scrapie.

作者信息

Davies Marie L, Hopkins Lee J, Halliday Sue, Houston Fiona, Hunter Nora, McConnell Ian

机构信息

Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK.

出版信息

Immunology. 2004 Feb;111(2):230-6. doi: 10.1111/j.0019-2805.2003.01789.x.

DOI:10.1111/j.0019-2805.2003.01789.x
PMID:15027909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1782407/
Abstract

Scrapie is a transmissible spongiform encephalopathy in which there is an accumulation of the abnormal form of the prion protein, PrPsc, in the lymphoreticular system and nervous system. There is a particular accumulation of PrPsc on follicular dendritic cells within the germinal centre of B-cell follicles. Because accumulation of PrPsc in the nervous system leads to neuronal cell loss we have examined PrPsc accumulation in the prescapular and mesenteric lymph nodes in relation to lymph node architecture of scrapie-challenged sheep. We demonstrate that an accumulation of PrPsc in the lymph node fails to result in gross defects in the microanatomy and phenotype of T- and B-cell areas in the lymph nodes.

摘要

羊瘙痒症是一种传染性海绵状脑病，其中朊病毒蛋白PrPsc的异常形式在淋巴网状系统和神经系统中积累。在B细胞滤泡生发中心的滤泡树突状细胞上有特别的PrPsc积累。由于PrPsc在神经系统中的积累导致神经元细胞丢失，我们研究了经羊瘙痒症攻击的绵羊肩胛前淋巴结和肠系膜淋巴结中PrPsc的积累与淋巴结结构的关系。我们证明，淋巴结中PrPsc的积累不会导致淋巴结中T细胞和B细胞区域的微观解剖结构和表型出现明显缺陷。