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隐睾症与生育能力的关系。

The relationship of cryptorchidism to fertility.

作者信息

Trussell J C, Lee Peter A

机构信息

Penn State College of Medicine, The Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033-0850, USA.

出版信息

Curr Urol Rep. 2004 Apr;5(2):142-8. doi: 10.1007/s11934-004-0028-4.

DOI:10.1007/s11934-004-0028-4
PMID:15028208
Abstract

Cryptorchidism is the most common genitourinary disorder of childhood, resulting in 27,000 surgical cases each year in the United States. Of the 3% of full-term infants affected, most will have testes that will descend normally within a few months. The remaining 1%, who have a cryptorchid condition that persists, should consider medical or surgical intervention. In addition, although the effect of cryptorchidism on testicular development and fertility has been studied extensively, the only fact of certainty is that untreated men with bilateral abdominal testes will be infertile. The remaining scenarios (unilateral, inguinal, gliding, and medically or surgically treated conditions) offer unpredictable levels of fertility. Fortunately, based on recent research, the correlation between testis maldescent and infertility may not be as prevalent as previously reported.

摘要

隐睾症是儿童期最常见的泌尿生殖系统疾病,在美国每年有27000例手术病例。在受影响的3%的足月儿中,大多数婴儿的睾丸会在几个月内正常下降。其余1%患有持续性隐睾症的婴儿,应考虑医学或手术干预。此外,尽管隐睾症对睾丸发育和生育能力的影响已得到广泛研究,但唯一确定的事实是,双侧腹内睾丸未经治疗的男性将无法生育。其余情况(单侧、腹股沟、滑动性以及经医学或手术治疗的情况)的生育能力难以预测。幸运的是,根据最近的研究,睾丸下降异常与不育之间的关联可能并不像先前报道的那么普遍。

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The relationship of cryptorchidism to fertility.隐睾症与生育能力的关系。
Curr Urol Rep. 2004 Apr;5(2):142-8. doi: 10.1007/s11934-004-0028-4.
2
Comparative studies of fertility and histologic development of contralateral scrotal testes in two rat models of unilateral cryptorchidism.两种单侧隐睾大鼠模型中对侧阴囊睾丸生育力和组织学发育的比较研究。
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[Future treatment strategies for cryptorchidism to improve spermatogenesis].[隐睾症改善精子发生的未来治疗策略]
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Clinical and biological characteristics of infertile men with a history of cryptorchidism.有隐睾病史的不育男性的临床和生物学特征。
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What is the relationship between spermatozoa per milliliter at adulthood and the tubular fertility index at surgical age for patients with cryptorchidism?对于隐睾症患者,成年期每毫升精子数与手术年龄时的睾丸生育指数之间有什么关系?
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Undescended testis: the effect of treatment on subsequent risk of subfertility and malignancy.隐睾症:治疗对后续生育力低下和恶性肿瘤风险的影响。
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Eur J Pediatr. 2025 May 24;184(6):361. doi: 10.1007/s00431-025-06190-w.
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Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling.通过单细胞转录组谱分析解码隐睾症中精子发生失败的发病机制。
Cell Rep Med. 2024 Sep 17;5(9):101709. doi: 10.1016/j.xcrm.2024.101709. Epub 2024 Sep 2.
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The Shehata technique for undescended testes that cannot be brought into the scrotum in one operation-a case series and meta-analysis.

本文引用的文献

1
CRYPTORCHID AND SCROTAL HUMAN TESTES. I. CYTOLOGICAL, CYTOCHEMICAL AND QUANTITATIVE STUDIES.隐睾和阴囊内的人类睾丸。I. 细胞学、细胞化学和定量研究。
J Clin Endocrinol Metab. 1965 Jul;25:927-42. doi: 10.1210/jcem-25-7-927.
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THE DESCENT OF THE TESTIS.睾丸的下降
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Unilateral cryptorchidism; subsequent effects on fertility.单侧隐睾症;对生育能力的后续影响。
对于一次手术无法降至阴囊的隐睾的谢哈塔技术——病例系列研究与荟萃分析
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To determine the sensitivity, specificity, and diagnostic accuracy of diffusion-weighted MRI in localization of non-palpable undescended testes taking laparoscopic findings as the gold standard: A cross-sectional study from Pakistan.以腹腔镜检查结果为金标准,确定扩散加权磁共振成像在不可触及隐睾定位中的敏感性、特异性和诊断准确性:一项来自巴基斯坦的横断面研究。
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Predictive factors for successful sperm retrieval by microdissection testicular sperm extraction in men with nonobstructive azoospermia and a history of cryptorchidism.隐睾症病史的非梗阻性无精子症患者通过微创睾丸精子抽吸术获得成功精子提取的预测因素。
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Apparent diffusion coefficient values of cryptorchid testes and malignant transformation of cryptorchidism (MTC) (seminoma) in postpubertal patients.隐睾睾丸的表观扩散系数值与隐睾恶变(MTC)(精原细胞瘤)在青春期后的患者。
Br J Radiol. 2021 Mar 1;94(1119):20200624. doi: 10.1259/bjr.20200624. Epub 2021 Jan 7.
7
Role of Ozone Therapy in Preventing Testicular Damage in an Experimental Cryptorchid Rat Model.臭氧疗法在预防实验性隐睾大鼠模型睾丸损伤中的作用。
Med Sci Monit. 2018 Aug 21;24:5832-5839. doi: 10.12659/MSM.910459.
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Cryptorchidism and Fertility.隐睾症与生育能力
Clin Med Insights Reprod Health. 2015 Dec 22;9:39-43. doi: 10.4137/CMRH.S25056. eCollection 2015.
9
Decreased expression of genes associated with memory and x-linked mental retardation in boys with non-syndromic cryptorchidism and high infertility risk.患有非综合征性隐睾症且不育风险高的男孩中,与记忆和X连锁智力迟钝相关的基因表达降低。
Mol Syndromol. 2014 Feb;5(2):76-80. doi: 10.1159/000357931. Epub 2014 Jan 29.
10
Prevalence of intratubular germ cell neoplasia in cryptorchid testes of infertile men.不育男性隐睾中管内生殖细胞瘤变的患病率。
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J Reprod Fertil. 1961 Feb;2:54-60. doi: 10.1530/jrf.0.0020054.
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Undescended testes: report of 153 cases with evaluation of clinical findings, treatment, and results on followup to thirty-three years.隐睾症:153例报告,对临床发现、治疗及长达33年随访结果的评估
J Urol. 1956 Jun;75(6):973-89. doi: 10.1016/S0022-5347(17)66912-X.
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Surgical experiences from 1,222 operations for undescended testis.1222例隐睾手术的外科经验。
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Infertility despite surgery for cryptorchidism in childhood can be classified by patients with normal or elevated follicle-stimulating hormone and identified at orchidopexy.童年期隐睾症手术后仍存在的不育症,可根据促卵泡激素正常或升高的患者进行分类,并在睾丸固定术中得以识别。
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Cryptorchidism, its impact on male fertility.
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Leydig cell function after cryptorchidism: evidence of the beneficial result of early surgery.
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Fertility after unilateral cryptorchidism. Paternity, time to conception, pretreatment testicular location and size, hormone and sperm parameters.单侧隐睾症后的生育能力。亲子关系、受孕时间、治疗前睾丸位置和大小、激素及精子参数。
Horm Res. 2001;55(5):249-53. doi: 10.1159/000050005.
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[TESE-ICSI in the treatment of secretory azoospermia secondary to cryptorchism. Report of a clinical case].[睾丸精子提取-卵胞浆内单精子注射治疗隐睾症继发的分泌性无精子症。1例临床病例报告]
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