使用单克隆抗体抗 Tac 进行全身放射免疫治疗，该抗体靶向白细胞介素 -2 受体的α亚基，并结合发射α粒子的放射性核素（212）Bi 或（211）At。
Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At.
作者信息
Wesley Jon N, McGee Edwin C, Garmestani Kayhan, Brechbiel Martin W, Yordanov Alexander T, Wu Chuanchu, Gansow Otto A, Eckelman William C, Bacher John D, Flynn Michael, Goldman Carolyn K, MacLin Melvin, Schwartz Uwe P, Jackson-White Terri, Phillip Celeste M, Decker Jean, Waldmann Thomas A
机构信息
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Nucl Med Biol. 2004 Apr;31(3):357-64. doi: 10.1016/j.nucmedbio.2003.08.011.
To exploit the fact that IL-2 receptors are expressed by T-cells responding to foreign antigens but not by resting T-cells, humanized anti-Tac (HAT) armed with alpha-emitting radionuclides (212)Bi and (211)At was evaluated in a cynomolgus cardiac allograft model. Control graft survival was 8.2+/- 0.5 days compared with 14.0+/-1.3 days (p<0.01) survival for monkeys treated with (212)Bi labeled HAT and 26.7+/-2.4 days survival (p<0.001 versus controls) with (211)At labeled HAT. Thus, (211)At labeled HAT may have application in organ transplantation and in treatment of IL-2 receptor expressing T-cell leukemia.
为利用白细胞介素-2受体由对外源抗原作出反应的T细胞表达而静止T细胞不表达这一事实，在食蟹猴心脏同种异体移植模型中评估了携带发射α射线的放射性核素铋-212和砹-211的人源化抗Tac（HAT）。对照移植物存活时间为8.2±0.5天，而用铋-212标记的HAT治疗的猴子移植物存活时间为14.0±1.3天（p<0.01），用砹-211标记的HAT治疗的猴子移植物存活时间为26.7±2.4天（与对照相比p<0.001）。因此，砹-211标记的HAT可能在器官移植和治疗表达白细胞介素-2受体的T细胞白血病中具有应用价值。
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