211砹和223镭在靶向α粒子放射治疗中的应用。
Applications of 211At and 223Ra in targeted alpha-particle radiotherapy.
作者信息
Vaidyanathan Ganesan, Zalutsky Michael R
机构信息
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Curr Radiopharm. 2011 Oct;4(4):283-94. doi: 10.2174/1874471011104040283.
Abstract
Targeted radiotherapy using agents tagged with α-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used α-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted α-particle radiotherapy.
摘要
使用标记有发射α粒子放射性核素的试剂进行靶向放射治疗正越来越受到关注，已经开展了多项临床试验，还有一些正在进行中，其他一些则处于高级规划阶段。最常用的发射α粒子放射性核素是213Bi、211At、223Ra和225Ac。虽然这些放射性核素各有优缺点，但基于其半衰期、衰变方案和化学性质，可以认为211At可能是最通用的。另一方面，对于靶向骨转移，223Ra是理想的放射性核素，因为简单的阳离子镭可用于此目的。在这篇综述中，我们将讨论211At标记的放射性药物应用方面的最新进展，并概述223Ra用于靶向α粒子放射治疗的现状。
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