使用PI指数对蝌蚪麻醉进行的定量构效关系研究：一组异类化合物的案例
QSAR study on tadpole narcosis using PI index: a case of heterogenous set of compounds.
作者信息
Jaiswal Mona, Khadikar Padmakar
机构信息
Research Division, Laxmi Fumigation & Pest Control (P), 3, Khatipura, Indore 452007, India.
出版信息
Bioorg Med Chem. 2004 Apr 1;12(7):1731-6. doi: 10.1016/j.bmc.2004.01.009.
PMID:15028264
Abstract
QSAR Study on Tadpole narcosis of heterogenous set of compounds has been carried out using a large set of distance-based topological indices, including logP as molecular descriptors. Excellent results are obtained in biparametric regression models. It was found that PI index, is superior to (0)chi,(2)chi and logP indices for modeling Tadpole narcosis.
摘要
利用包括logP在内的大量基于距离的拓扑指数，对一组异类化合物的蝌蚪麻醉进行了定量构效关系（QSAR）研究。在双参数回归模型中获得了优异的结果。研究发现，对于模拟蝌蚪麻醉，PI指数优于（0）χ、（2）χ和logP指数。
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