Love Jeffrey N, Sikka Neal
Department of Emergency Medicine, Georgetown University Hospital, Washington, DC 20057, USA.
J Emerg Med. 2004 Apr;26(3):309-14. doi: 10.1016/j.jemermed.2003.11.015.
The common use and wide availability of beta-adrenergic blocking agents make them frequent ingestants for small children. Yet, there are no clear guidelines in the literature to direct the care of the toddler with the history of ingesting 1-2 tablets. With 40 years of extensive clinical experience, not one documented case of death or serious cardiovascular morbidity as a direct result of a beta-blocker exposure is to be found in an English language review for children under 6 years of age. As with children on chronic beta-blocker therapy, several cases of symptomatic hypoglycemia associated with a single acute propranolol exposure suggest a vulnerability to this complication. Though the risk to the toddler exposed to 1-2 tablets appears to be extremely small, several factors mitigate the actual risk to the child and the need for triage to a health care facility.
β-肾上腺素能阻滞剂的广泛使用和易于获取，使其成为幼儿经常摄入的药物。然而，文献中没有明确的指南来指导对有摄入1 - 2片药物史的幼儿的护理。在对6岁以下儿童的英文综述中，没有发现一例因接触β受体阻滞剂而直接导致死亡或严重心血管疾病的记录病例。与接受慢性β受体阻滞剂治疗的儿童一样，几例与单次急性普萘洛尔暴露相关的症状性低血糖病例表明存在发生这种并发症的易感性。尽管接触1 - 2片药物的幼儿风险似乎极小，但有几个因素可减轻对儿童的实际风险以及将其分诊至医疗机构的必要性。
