Gondi Jonathan Theodore, Gazula Suhasini, Rajasekhar A, Usharani G
Department of Head and Neck Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
Department of Pediatric Surgery, Employees State Insurance Corporation, Super Speciality Hospital, Hyderabad, Telangana, India.
Contemp Clin Dent. 2016 Apr-Jun;7(2):269-72. doi: 10.4103/0976-237X.183060.
Infantile hemangiomas (IHs) are common, benign vascular tumors of infancy, with more than half affecting the head and neck region. IHs involving the lips and oral cavity can often present to the oral surgeon and the pedodontist. Till date, several doubts exist among clinicians regarding the use of propranolol to treat infantile hemangiomas in neonates and small infants, appropriate dose, treatment duration, side effects, response, and long-term follow-up. We present a 2-month-old male infant with extensive hemangioma involving the face, orbit, buccal mucosa and palate with feeding difficulties, and risk of life-threatening complications such as airway compromise, aspiration, and visual loss which showed excellent response with high-dose propranolol and had no side effects. We also reviewed literature for the mechanism of action of propranolol and possible minor and serious side effects.
婴儿血管瘤（IHs）是常见的婴儿期良性血管肿瘤，超过半数累及头颈部区域。累及唇部和口腔的婴儿血管瘤常需口腔外科医生和儿童牙医处理。迄今为止，临床医生对于使用普萘洛尔治疗新生儿和小婴儿的婴儿血管瘤、合适剂量、治疗持续时间、副作用、反应及长期随访仍存在诸多疑问。我们报告一例2个月大的男婴，患有广泛的血管瘤，累及面部、眼眶、颊黏膜和腭部，存在喂养困难，并有气道梗阻、误吸和视力丧失等危及生命并发症的风险，该患儿使用高剂量普萘洛尔治疗后反应良好且无副作用。我们还查阅了文献，了解普萘洛尔的作用机制以及可能的轻微和严重副作用。
