随机过程影响枯草芽孢杆菌的稳定期决策。
Stochastic processes influence stationary-phase decisions in Bacillus subtilis.
作者信息
Maughan Heather, Nicholson Wayne L
机构信息
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA.
出版信息
J Bacteriol. 2004 Apr;186(7):2212-4. doi: 10.1128/JB.186.7.2212-2214.2004.
Abstract
It has recently been proposed that phenotypic variation in clonal populations of bacterial species results from intracellular "noise," i.e., random fluctuations in levels of cellular molecules, which would be predicted to be insensitive to selective pressure. To test this notion, we propagated five populations of Bacillus subtilis for 5,000 generations with selection for one phenotype: the decision to sporulate. In support of the noise hypothesis, we report that none of the populations responded to selection by improving their efficiency of sporulation, indicating that intracellular noise is independent of heritable genotype.
摘要
最近有人提出，细菌物种克隆群体中的表型变异源于细胞内的“噪声”，即细胞分子水平的随机波动，预计这种波动对选择压力不敏感。为了验证这一观点，我们对五个枯草芽孢杆菌群体进行了5000代的传代培养，并针对一种表型进行选择：形成芽孢的决定。为支持噪声假说，我们报告称，没有一个群体通过提高其芽孢形成效率来响应选择，这表明细胞内噪声与可遗传的基因型无关。
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