Fukuda T, Aihara T, Ban S, Nakajima T, Machinami R
Second Department of Pathology, Gunma University School of Medicine, Japan.
Acta Pathol Jpn. 1992 Jun;42(6):448-53.
Two autopsy cases of sacrococcygeal chordoma which showed sarcomatous components in the primary and metastatic tumors are reported. Case 1 was a 48-year-old female who died 9 years after the development of the initial symptoms. Autopsy findings showed metastatic tumors consisted of malignant tumor cells similar to fibrosarcoma and osteosarcoma. Case 2 was a 63-year-old male who died 11 years after the development of the initial symptom. At autopsy only sarcomatous tumors resembling malignant fibrous histiocytoma (MFH) were observed in the metastatic lesions. Both cases were treated with irradiation. It is suggested that the appearance of sarcomatous tumor in current two cases of chordoma might be due to the phenomenon of tumor progression closely associated with irradiation therapy. These two cases can be categorized as "chordoma with a malignant spindle cell component" in a sense that highly malignant sarcomatous components existed in conjunction with chordoma in the primary tumors.
报告了两例骶尾部脊索瘤尸检病例，其原发肿瘤和转移瘤中均显示有肉瘤成分。病例1为一名48岁女性，在出现初始症状9年后死亡。尸检结果显示转移瘤由类似于纤维肉瘤和骨肉瘤的恶性肿瘤细胞组成。病例2为一名63岁男性，在出现初始症状11年后死亡。尸检时在转移灶中仅观察到类似于恶性纤维组织细胞瘤（MFH）的肉瘤样肿瘤。两例均接受了放疗。提示目前这两例脊索瘤中肉瘤样肿瘤的出现可能是与放疗密切相关的肿瘤进展现象所致。从原发肿瘤中高度恶性的肉瘤成分与脊索瘤并存的意义上来说，这两例可归类为“伴有恶性梭形细胞成分的脊索瘤 ”。
