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[孢子丝菌样非典型分枝杆菌感染。抗生素单一疗法]

[Sporotrichoid atypical mycobacterial infections. Antibiotic monotherapy].

作者信息

Bormann G, Marsch W C

机构信息

Universitätsklinik und Poliklinik für Dermatologie und Venerologie der Martin-Luther-Universität Halle-Wittenberg, Halle (Saale).

出版信息

Hautarzt. 2004 Mar;55(3):292-5. doi: 10.1007/s00105-003-0679-y.

DOI:10.1007/s00105-003-0679-y
PMID:15029437
Abstract

Sporotrichoid forms of atypical mycobacterial infections usually do not show a tendency to spontaneous healing. The therapy of choice in such cases is systemic antibiotics. We report three cases of sporotrichoid atypical mycobacterial infections of the skin which healed completely under long-term monotherapy with modern antibiotics (levofloxacin, clarithromycin, minocycline). We recommend confirming the diagnosis by means of culture, followed by monotherapy with low side-effect antibiotics, based on sensitivity studies. If pathogen proof is obtained by PCR, antibiotic therapy should be based on the known sensitivity of the pathogen in question.

摘要

非典型分枝杆菌感染的孢子丝菌病样型通常没有自愈倾向。此类病例的首选治疗方法是全身使用抗生素。我们报告了3例皮肤孢子丝菌病样非典型分枝杆菌感染病例,这些病例在使用现代抗生素(左氧氟沙星、克拉霉素、米诺环素)进行长期单一治疗后完全治愈。我们建议通过培养来确诊,然后根据药敏试验,使用低副作用抗生素进行单一治疗。如果通过聚合酶链反应获得病原体证据,抗生素治疗应基于所涉病原体已知的敏感性。

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本文引用的文献

1
Efficacy of oral minocycline and hyperthermic treatment in a case of atypical mycobacterial skin infection by Mycobacterium marinum.
J Dermatol. 2002 Dec;29(12):810-1. doi: 10.1111/j.1346-8138.2002.tb00228.x.
2
Diagnostic odyssey of a cutaneous mycobacteriosis rare in central Europe.中欧罕见皮肤分枝杆菌病的诊断历程
Dermatology. 2002;205(3):289-92. doi: 10.1159/000065854.
3
Atypical cutaneous mycobacteriosis diagnosed by polymerase chain reaction.通过聚合酶链反应诊断的非典型皮肤分枝杆菌病
Br J Dermatol. 2002 Oct;147(4):781-4. doi: 10.1046/j.1365-2133.2002.04903.x.
4
Sixty-three cases of Mycobacterium marinum infection: clinical features, treatment, and antibiotic susceptibility of causative isolates.63例海分枝杆菌感染:致病菌株的临床特征、治疗及抗生素敏感性
Arch Intern Med. 2002;162(15):1746-52. doi: 10.1001/archinte.162.15.1746.
5
Sporotrichoid spread of Mycobacterium chelonae in a presumably immunocompetent patient.龟分枝杆菌在一名推测免疫功能正常的患者中的孢子丝菌病样播散。
Acta Derm Venereol. 2002;82(2):142-3. doi: 10.1080/00015550252948248.
6
A case of cutaneous Mycobacterium chelonae abscessus infection in a renal transplant patient.一名肾移植患者发生皮肤龟分枝杆菌脓肿感染病例。
J Cutan Med Surg. 2001 Jan-Feb;5(1):28-32. doi: 10.1177/120347540100500107.
7
Mycobacterium chelonae infection resistant to clarithromycin in a patient with dermatomyositis.
Br J Dermatol. 2000 Dec;143(6):1345. doi: 10.1046/j.1365-2133.2000.03931.x.
8
Skin disease and nontuberculous atypical mycobacteria.皮肤病与非结核性非典型分枝杆菌
Int J Dermatol. 2000 Sep;39(9):659-66. doi: 10.1046/j.1365-4362.2000.00821.x.
9
[Sporotrichoid infection with Mycobacterium marinum: successful therapy with oral tetracycline administration].[海分支杆菌所致孢子丝菌病样感染:口服四环素治疗成功]
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10
Cutaneous manifestations of infection by nontuberculous mycobacteria.非结核分枝杆菌感染的皮肤表现
Clin Exp Dermatol. 1998 Sep;23(5):214-21. doi: 10.1046/j.1365-2230.1998.00359.x.