Kusec Rajko, Kusec Vesna, Gisslinger Bettina, Woloszczuk Wolfgang, Gisslinger Heinz
Institute of Clinical Chemistry and Department of Medicine, University Hospital Merkur, Zagreb, Croatia.
Wien Klin Wochenschr. 2004 Jan 31;116(1-2):37-41. doi: 10.1007/BF03040422.
In-vitro studies have demonstrated that interferon (IFN) has an inhibitory effect on bone formation. Changes in bone metabolism were investigated in 19 patients treated for essential thrombocythemia with IFN-alpha. Serum biochemical parameters of bone remodeling [total alkaline phosphatase, osteocalcin, type-I procollagen carboxy-terminal propeptide (PICP), cross-linked telopeptide type-I collagen (ICTP)] and mineral metabolism (total calcium, inorganic phosphate, parathyroid hormone, 25-hydroxyvitamin D) were measured before and after long-term IFN-alpha treatment. The effects of the cumulative IFN-alpha dose and duration of therapy on biochemical markers of bone metabolism were analyzed. No uniform trend or pattern was observed in the measured biochemical parameters except for ICTP, which decreased after treatment. Correlations indicated modulation of bone metabolism, i.e. remodeling with suppression of resorption, as a consequence of therapy with IFN-alpha.
体外研究表明，干扰素（IFN）对骨形成具有抑制作用。对19例接受α-干扰素治疗原发性血小板增多症的患者的骨代谢变化进行了研究。在长期α-干扰素治疗前后，测量了骨重塑的血清生化参数[总碱性磷酸酶、骨钙素、I型前胶原羧基末端前肽（PICP）、I型胶原交联端肽（ICTP）]和矿物质代谢参数（总钙、无机磷、甲状旁腺激素、25-羟基维生素D）。分析了α-干扰素累积剂量和治疗持续时间对骨代谢生化标志物的影响。除ICTP在治疗后下降外，在所测量的生化参数中未观察到一致的趋势或模式。相关性表明，α-干扰素治疗可调节骨代谢，即通过抑制骨吸收来进行重塑。
