Smalcelj R, Kusec V, Puretić Z, Mareković Z
Urology Department, Clinical Hospital Center Zagreb, Croatia.
Wien Klin Wochenschr. 1998 May 8;110(9):326-30.
Impairment of bone remodelling due to chronic renal failure persists even after successful kidney transplantation. Bone turnover was assessed in 22 kidney transplant recipients by measurement of serum bone markers: total (tALP) and bone alkaline phosphatase (bALP), osteocalcin (OC), procollagen I C-terminal propeptide (PICP), collagen I C-terminal telopeptide (ICTP), and iPTH. The patients were on dialysis 56.6 +/- 43.1 months before transplantation (mean +/- SD) and 34.2 +/- 23.0 months had elapsed after transplantation. The bone markers were within the reference range in 23% of patients for iPTH, 73% for tALP and 82% for bALP, 41% for OC, 73% for PICP and 50% for ICTP. A positive correlation was found between dialysis duration and ICTP, and iPTH and bone formation markers (OC, bALP). The obtained results indicate that bone turnover was increased after kidney transplantation, with prevailing bone resorption, which seems to be influenced by dialysis duration.
即使在成功进行肾移植后，慢性肾衰竭所致的骨重塑损害仍持续存在。通过测量血清骨标志物评估了22例肾移植受者的骨转换情况：总碱性磷酸酶（tALP）和骨碱性磷酸酶（bALP）、骨钙素（OC）、前胶原I C端前肽（PICP）、胶原I C端末肽（ICTP）和iPTH。患者在移植前接受透析56.6±43.1个月（均值±标准差），移植后已过去34.2±23.0个月。骨标志物在23%的患者中iPTH、73%的患者中tALP、82%的患者中bALP、41%的患者中OC、73%的患者中PICP以及50%的患者中ICTP处于参考范围内。发现透析时间与ICTP以及iPTH与骨形成标志物（OC、bALP）之间存在正相关。所获结果表明肾移植后骨转换增加，以骨吸收为主，这似乎受透析时间影响。
