Elema J D, Poppema S
Cancer. 1978 Aug;42(2):555-65. doi: 10.1002/1097-0142(197808)42:2<555::aid-cncr2820420223>3.0.co;2-g.
Skin biopsies and a lymphnode of three children with infantile Histiocytosis-X (Letter-Siwe Disease) were studied with enzymehistochemical and sheep-erythrocyte rosetting techniques. The majority of cells making up the infiltrates of skin and lymphnode showed rather weak acid phosphatase and nonspecific esterase activity but considerable leucyl-beta-naphtylamidase activity. Sheep-erythrocyte rosetting techniques performed on frozen sections indicated the presence of receptors for the Fc fragment of IgG, but no receptors for C3 could be demonstrated. Cells with the same enzymehistochemical characteristics could be found in thymus-dependent areas of normal spleen, of normal and reactive lymphnodes and in thymic medulla but not in B-cell areas or thymic cortex. It is suggested that Histiocytosis-X cells belong to the Mononuclear Phagocyte System and that they are related to or identical with cells normally present in the thymus dependent areas of the lymphoid tissue involved with the functioning of cell-mediated immunity.
对三名患有婴儿型组织细胞增生症-X（勒-雪氏病）儿童的皮肤活检标本及一个淋巴结，采用酶组织化学和绵羊红细胞玫瑰花结形成技术进行了研究。构成皮肤和淋巴结浸润的大多数细胞显示出相当弱的酸性磷酸酶和非特异性酯酶活性，但亮氨酰-β-萘酰胺酶活性相当高。对冰冻切片进行的绵羊红细胞玫瑰花结形成技术表明存在IgG的Fc片段受体，但未发现C3受体。具有相同酶组织化学特征的细胞可见于正常脾脏、正常及反应性淋巴结的胸腺依赖区以及胸腺髓质，但不见于B细胞区或胸腺皮质。提示组织细胞增生症-X细胞属于单核吞噬细胞系统，且它们与参与细胞介导免疫功能的淋巴组织胸腺依赖区中正常存在的细胞相关或相同。
