Feltkamp C A, van Heerde P, Feltkamp-Vroom T M, Koudstaal J
Virchows Arch A Pathol Anat Histol. 1981;393(2):183-92. doi: 10.1007/BF00431075.
A tumor in a 37 years old male is described in which the tumor cells appeared to be derived from interdigitating cells normally found in the T-cell area of lymph nodes. The patient presented with superior vena caval obstruction due to a mediastinal mass, followed by lymph node enlargement and skin lesions leading to death within 4 months. The tumor cells lacked immune markers for lymphocytic cells. They showed Ia-like antigens and high adenosine triphosphatase activity, while acid phosphatase and alpha-naphthyl acetate esterase activity was absent. Their fine morphology was strikingly similar to that of interdigitating cells. A combination of these data led us to the conclusion that this tumor represents a specific subtype of the tumors derived from the mononuclear phagocyte system, namely a sarcoma of interdigitating cells.
本文描述了一名37岁男性的肿瘤，其肿瘤细胞似乎来源于通常在淋巴结T细胞区发现的指状突细胞。患者因纵隔肿块出现上腔静脉阻塞，随后出现淋巴结肿大和皮肤病变，在4个月内死亡。肿瘤细胞缺乏淋巴细胞的免疫标志物。它们显示出Ia样抗原和高腺苷三磷酸酶活性，而酸性磷酸酶和α-萘乙酸酯酶活性缺失。它们的精细形态与指状突细胞非常相似。这些数据综合起来使我们得出结论，该肿瘤代表了源自单核吞噬细胞系统的肿瘤的一种特定亚型，即指状突细胞肉瘤。
