[Cardiovascular disease in HIV-infected patients on highly active antiretroviral therapy].
作者信息
Jericó Carlos, Knobel Hernando, Carmona Alexia, Sorli M Luisa, López-Colomés José Luis, Pedro-Botet Juan
机构信息
Servicio de Medicina Interna-Enfermedades Infecciosas, Hospital del Mar, Universidad Autónoma de Barcelona, Spain.
出版信息
Med Clin (Barc). 2004 Mar 6;122(8):298-300. doi: 10.1016/s0025-7753(04)74214-1.
BACKGROUND AND OBJECTIVE
Our goal was to assess the main characteristics of cardiovascular disease in HIV-infected patients on highly active antiretroviral therapy (HAART).
PATIENTS AND METHOD
Retrospective analysis of the clinico-epidemiological characteristics of 16 HIV-infected patients treated with HAART who had suffered a cardiovascular event from a 1,459 patients' cohort.
RESULTS
Clinical presentation of cardiovascular disease was an acute coronary syndrome in 12 cases, ischemic stroke in 2 and peripheral vascular disease in 2. Patients included in the study had a mean of 3.2 cardiovascular risk factors, smoking and low HDL levels being the more prevalent risk factors. Eight (50%, 95% CI, 25-75%) patients fulfilled the criteria of metabolic syndrome. The mean CD4 count was 548 x 10(6)/l.
CONCLUSIONS
HIV-infected patients on HAART ha-ve a high cardiovascular risk. A strict management of modifiable risk factors must be warranted in these patients.
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