Kronenberg Henry M
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA 02114, USA.
Dev Cell. 2004 Mar;6(3):317-8. doi: 10.1016/s1534-5807(04)00069-3.
Runx2, a master regulator of osteoblast differentiation, is expressed several days before osteoblast genes in bone anlage. In this issue of Developmental Cell, show that Twist-1 and Twist-2 suppress the activity of Runx2 and thereby regulate bone formation.
成骨细胞分化的主要调节因子Runx2在骨原基中早于成骨细胞基因数天表达。在本期《发育细胞》中，研究表明Twist-1和Twist-2抑制Runx2的活性，从而调节骨形成。
