O'Connell Kristen M S, Martens Jeffrey R, Tamkun Michael M
Kristen M.S. O'Connell and Michael M. Tamkun are at the Department of Biomedical Sciences, Colorado State University, Ft. Collins, Colorado 80523, USA.
Trends Cardiovasc Med. 2004 Feb;14(2):37-42. doi: 10.1016/j.tcm.2003.10.002.
The subcellular localization of ion channels to discrete microdomains is critical for proper electrical signaling in the cardiovascular system. Ion channels are important components of many signal transduction pathways; therefore, this localization ensures that the channels are located in proximity to the signaling molecules that modulate them, permitting dynamic regulation of cardiovascular function. However, little is known about the mechanisms governing the subcellular localization of ion channels. Whereas protein-protein interactions play an important role in ion channel localization, the recent discovery of ion channels in sphingolipid- and cholesterol-rich lipid rafts presents a novel mechanism for ion channel localization. Furthermore, many signaling proteins are localized to lipid rafts, including several that play an important role in cardiovascular function. This review focuses on the localization of cardiovascular ion channels to lipid rafts and its impact on channel function.
离子通道在亚细胞水平定位于离散的微结构域对于心血管系统中正常的电信号传导至关重要。离子通道是许多信号转导途径的重要组成部分；因此，这种定位确保通道位于调节它们的信号分子附近，从而实现对心血管功能的动态调节。然而，关于离子通道亚细胞定位的调控机制我们所知甚少。虽然蛋白质-蛋白质相互作用在离子通道定位中起重要作用，但最近在富含鞘脂和胆固醇的脂筏中发现离子通道，为离子通道定位提供了一种新机制。此外，许多信号蛋白定位于脂筏，其中包括几种在心血管功能中起重要作用的蛋白。本综述重点关注心血管离子通道在脂筏中的定位及其对通道功能的影响。
