Vascular Biology Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark.
Acta Physiol (Oxf). 2021 Jul;232(3):e13692. doi: 10.1111/apha.13692. Epub 2021 Jun 4.
In arterial smooth muscle cells, changes in availability of integral membrane proteins influence the regulation of blood flow and blood pressure, which is critical for human health. However, the mechanisms that coordinate the trafficking and membrane expression of specific receptors and ion channels in vascular smooth muscle are poorly understood. In the vasculature, very little is known about microtubules, which form a road network upon which proteins can be transported to and from the cell membrane. This review article summarizes the impact of the microtubule network on arterial contractility, highlighting the importance of the network, with an emphasis on our recent findings regarding the trafficking of the voltage-dependent Kv7 channels.
在动脉平滑肌细胞中，整合膜蛋白的可用性变化会影响血流和血压的调节，这对人类健康至关重要。然而，血管平滑肌中特定受体和离子通道的运输和膜表达的协调机制还知之甚少。在脉管系统中，人们对微管知之甚少，微管形成了一个路网，蛋白质可以在细胞内外运输。这篇综述文章总结了微管网络对动脉收缩性的影响，强调了网络的重要性，并重点介绍了我们最近关于电压依赖性 Kv7 通道运输的发现。
