Mohebbi Mohammad R, Holden Kenton R, Mohammadi Mahmoud
Students' Scientific Research Center, Bahrami Children's Hospital, Tehran University of Medical Sciences, Iran.
J Child Neurol. 2004 Jan;19(1):47-50. doi: 10.1177/08830738040190010704.
Peripheral blood leukocytosis has been reported following febrile seizures as a result of infection, the seizure, or both. To examine this relationship, 238 consecutive children < 5 years of age who experienced their first febrile seizure were evaluated. Lumbar punctures were electively done on 128 of the children to rule out central nervous system infection. Total leukocyte counts and duration of fever before the seizure were negatively correlated (r = - .175, P < .05). In logistic regression analysis, the logarithm of fever duration before the seizure was negatively associated with leukocytosis (leukocyte count > or = 15,000 cells/microL [odds ratio: 0.117, P < .05]). Cerebrospinal fluid glucose concentrations were significantly correlated with increased body temperature (r = .230, P < .05) and increased leukocyte counts (r = .255, P < .01). No significant association was found between leukocyte counts and the characteristics of the febrile seizure event. By all indications, changes in leukocyte counts appear more likely to be related to the length and underlying etiology of the fever than to the seizure itself.
据报道，热性惊厥后出现外周血白细胞增多是由感染、惊厥或两者共同引起的。为了研究这种关系，对238名连续发生首次热性惊厥的5岁以下儿童进行了评估。对其中128名儿童选择性地进行了腰椎穿刺以排除中枢神经系统感染。惊厥前的白细胞总数与发热持续时间呈负相关（r = -0.175，P < 0.05）。在逻辑回归分析中，惊厥前发热持续时间的对数与白细胞增多呈负相关（白细胞计数≥15,000个/微升[比值比：0.117，P < 0.05]）。脑脊液葡萄糖浓度与体温升高（r = 0.230，P < 0.05）和白细胞计数增加（r = 0.255，P < 0.01）显著相关。未发现白细胞计数与热性惊厥事件的特征之间存在显著关联。种种迹象表明，白细胞计数的变化似乎更可能与发热的时长和潜在病因有关，而非惊厥本身。
