[转化生长因子β及其受体在增生性瘢痕中的分布与表达]
[Distribution and expression of transforming growth factor beta and their receptors in hypertrophic scar].
作者信息
Lu Luo, Chen Yu-lin, Zhang Qing-guo
机构信息
Department of Burns, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China.
出版信息
Zhonghua Shao Shang Za Zhi. 2004 Feb;20(1):30-3.
OBJECTIVE
To explore the role of transforming growth factor beta (TGF beta) and their receptors (TGF beta-R) in the pathogenesis of hypertrophic scar.
METHODS
Specimens of normal skin and hypertrophic scar were harvested and the distribution and the expression of the TGF beta and TGF beta-R were determined by immunohistochemistry and in situ hybridization method.
RESULTS
The expressions of TGF beta and TGF beta-RII in normal skin were higher than the expression of TGF beta 1, TGF beta 2 and TGF-RI. But in hypertrophic scar the results were on the contrary. The mRNA expressions of TGF beta 1, TGF beta 2 and TGFRI were evidently increased with decreased mRNA expression of TGF-beta 3 and TGFR II in the hypertrophic scar when compared with those in the normal skin.
CONCLUSION
The expression of TGF-beta (beta 1, beta 2, beta 3) and their receptors in different levels during the process of wound healing might be related to the formation of hypertrophic scars.
目的
探讨转化生长因子β（TGFβ）及其受体（TGFβ-R）在增生性瘢痕发病机制中的作用。
方法
采集正常皮肤和增生性瘢痕标本，采用免疫组织化学和原位杂交方法检测TGFβ及TGFβ-R的分布和表达。
结果
正常皮肤中TGFβ和TGFβ-RII的表达高于TGFβ1、TGFβ2和TGF-RI的表达。但在增生性瘢痕中结果相反。与正常皮肤相比，增生性瘢痕中TGFβ1、TGFβ2和TGFRI的mRNA表达明显增加，而TGF-β3和TGFR II的mRNA表达降低。
结论
伤口愈合过程中不同水平的TGF-β（β1、β2、β3）及其受体的表达可能与增生性瘢痕的形成有关。
Zotero 插件