临床自由基清除剂依达拉奉可保护耳蜗毛细胞免受声损伤。
The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma.
作者信息
Takemoto Tsuyoshi, Sugahara Kazuma, Okuda Takeshi, Shimogori Hiroaki, Yamashita Hiroshi
机构信息
Department of Otolaryngology, Yamaguchi University School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan.
出版信息
Eur J Pharmacol. 2004 Mar 8;487(1-3):113-6. doi: 10.1016/j.ejphar.2004.01.019.
It is known that reactive oxygen species have toxicity to the cochlea. We investigated the effect of edaravone, a free radical scavenger for clinical use, on the cochleae of guinea pigs subjected to acoustic trauma. We assessed auditory brainstem response (ABR) thresholds to evaluate cochlear function and observed the sensory epithelium. After noise exposure (130 dB SPL, 3 h), we observed that the auditory brainstem response threshold shift in edaravone-treated ears was significantly less than that in untreated ears. This result suggests that edaravone protected the cochleae from acoustic trauma.
已知活性氧对耳蜗具有毒性。我们研究了临床使用的自由基清除剂依达拉奉对遭受声创伤的豚鼠耳蜗的影响。我们评估了听性脑干反应（ABR）阈值以评估耳蜗功能，并观察了感觉上皮。在噪声暴露（130 dB SPL，3小时）后，我们观察到依达拉奉治疗组耳朵的听性脑干反应阈值变化明显小于未治疗组耳朵。这一结果表明依达拉奉保护耳蜗免受声创伤。
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