CILcare, Montpellier, France.
School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas 75080, USA.
J Acoust Soc Am. 2019 Nov;146(5):3743. doi: 10.1121/1.5132711.
Guinea pigs have been used in diverse studies to better understand acquired hearing loss induced by noise and ototoxic drugs. The guinea pig has its best hearing at slightly higher frequencies relative to humans, but its hearing is more similar to humans than the rat or mouse. Like other rodents, it is more vulnerable to noise injury than the human or nonhuman primate models. There is a wealth of information on auditory function and vulnerability of the inner ear to diverse insults in the guinea pig. With respect to the assessment of potential otoprotective agents, guinea pigs are also docile animals that are relatively easy to dose via systemic injections or gavage. Of interest, the cochlea and the round window are easily accessible, notably for direct cochlear therapy, as in the chinchilla, making the guinea pig a most relevant and suitable model for hearing. This article reviews the use of the guinea pig in basic auditory research, provides detailed discussion of its use in studies on noise injury and other injuries leading to acquired sensorineural hearing loss, and lists some therapeutics assessed in these laboratory animal models to prevent acquired sensorineural hearing loss.
豚鼠在多种研究中被用于更好地理解噪声和耳毒性药物引起的获得性听力损失。豚鼠的最佳听力频率相对人类稍高，但与大鼠或小鼠相比，豚鼠的听力与人类更相似。与其他啮齿动物一样，豚鼠比人类或非人类灵长类动物模型更容易受到噪声损伤。豚鼠在听觉功能和内耳对各种刺激的易感性方面有丰富的信息。就潜在的耳保护剂的评估而言，豚鼠也是温顺的动物，通过系统注射或灌胃给药相对容易。有趣的是，耳蜗和圆窗很容易接近，特别是对于直接的耳蜗治疗，就像在南美栗鼠中一样，这使得豚鼠成为听力方面最相关和最合适的模型。本文综述了豚鼠在基础听觉研究中的应用，详细讨论了其在噪声损伤和其他导致获得性感觉神经性听力损失的研究中的应用，并列出了一些在这些实验动物模型中评估的治疗方法，以预防获得性感觉神经性听力损失。
