肝细胞生长因子/散射因子对JNK的抑制作用可防止肿瘤坏死因子-α诱导的细胞凋亡。
Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-alpha.
作者信息
Reveneau Sylvie, Paumelle Réjane, Deheuninck Julien, Leroy Catherine, De Launoit Yvan, Fafeur Véronique
机构信息
Ecole Pratique des Hautes Etudes, Institut National de la Santé et de la Recherche Médicale U517, BP 87900, 21079 Dijon, France.
出版信息
Ann N Y Acad Sci. 2003 Dec;1010:100-3. doi: 10.1196/annals.1299.016.
We investigated whether repression of JNK by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF-alpha, a well-known inducer of JNK and of cell death, and the effects of HGF/SF were investigated under these conditions. We identified repression of JNK as a signaling target of HGF/SF for protection against TNF-alpha-induced cell death. This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.
我们研究了在MDCK上皮细胞中，肝细胞生长因子/分散因子（HGF/SF）对JNK的抑制作用是否与其保护细胞免受凋亡的能力有关。为此，用肿瘤坏死因子-α（TNF-α，一种众所周知的JNK和细胞死亡诱导剂）处理细胞，并在这些条件下研究HGF/SF的作用。我们确定JNK的抑制是HGF/SF对抗TNF-α诱导的细胞死亡的信号转导靶点。HGF/SF的这种作用是通过激活PI3K和MEK1途径实现的。
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