Akundi Ravi Shankar, Hüll Michael, Clement Hans Willi, Fiebich Bernd L
Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, Freiburg 79104, Germany.
Ann N Y Acad Sci. 2003 Dec;1010:304-6. doi: 10.1196/annals.1299.053.
The former popular hypnotic chloral hydrate has been known to spontaneously condense with tryptamine in the body to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) derivative. Earlier studies have revealed the relative permeability of the molecule through the body, and its ability to induce Parkinson-like symptoms in rats. In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation.
曾经流行的催眠药水合氯醛已知会在体内与色胺自发缩合，生成一种高度非极性的1-三氯甲基-1,2,3,4-四氢-β-咔啉（TaClo）衍生物。早期研究揭示了该分子在体内的相对渗透性，以及它在大鼠中诱发帕金森样症状的能力。在本研究中，我们报告TaClo是一种高度细胞毒性剂，可导致人神经母细胞瘤细胞凋亡，涉及半胱天冬酶-3激活。
