Suppr超能文献

开胸术后0.1%布比卡因中硬膜外芬太尼的最佳浓度。

Optimal concentration of epidural fentanyl in bupivacaine 0.1% after thoracotomy.

作者信息

Tan C N H, Guha A, Scawn N D A, Pennefather S H, Russell G N

机构信息

Department of Anaesthesia, The Cardiothoracic Centre, Liverpool, Thomas Drive, Liverpool L14 3PE, UK.

出版信息

Br J Anaesth. 2004 May;92(5):670-4. doi: 10.1093/bja/aeh129. Epub 2004 Mar 19.

Abstract

BACKGROUND

The aim of this prospective, double-blind, randomized controlled trial was to investigate the analgesic and adverse effects of three commonly used concentrations of thoracic epidural fentanyl with bupivacaine in patients undergoing thoracotomy for lung resection.

METHODS

We studied 99 patients who were randomized to receive fentanyl 2 microg ml(-1) (group 2), fentanyl 5 microg ml(-1) (group 5) and fentanyl 10 microg ml(-1) (group 10) in bupivacaine 0.1% via a thoracic epidural. Postoperatively, pain on coughing was assessed using a visual analogue scale (VAS) and an observer verbal rating score (OVRS) at 2, 8, 16 and 24 h. At the same times, sedation, pruritus and nausea were assessed.

RESULTS

Of 29, 28 and 32 patients who completed the study in groups 2, 5 and 10 respectively, there was no significant difference in baseline characteristics between the three groups. The number of patients with episodes of unsatisfactory pain, i.e. VAS scores >30 mm and OVRS >1, at each of the four assessments postoperatively was significantly (P<0.01) higher in group 2 than in groups 5 and 10. In group 10, 16 patients had sedation scores >1 compared with 10 each in groups 2 and 5. In addition, 19 patients in group 10 experienced pruritus compared with 12 each, in groups 2 and 5. These differences were not significant. Nausea was not significantly different between the three groups.

CONCLUSION

We conclude that thoracic epidural fentanyl 5 microg ml(-1) with bupivacaine 0.1% provides the optimum balance between pain relief and side effects following thoracotomy.

摘要

背景

这项前瞻性、双盲、随机对照试验的目的是研究三种常用浓度的芬太尼与布比卡因用于开胸肺切除术患者胸段硬膜外镇痛的效果及不良反应。

方法

我们研究了99例患者,随机分为三组,通过胸段硬膜外给予0.1%布比卡因,分别加入芬太尼2μg/ml(2组)、芬太尼5μg/ml(5组)和芬太尼10μg/ml(10组)。术后,在2、8、16和24小时使用视觉模拟评分法(VAS)和观察者语言评分(OVRS)评估咳嗽时的疼痛。同时,评估镇静、瘙痒和恶心情况。

结果

2组、5组和10组分别有29例、28例和32例患者完成研究,三组患者的基线特征无显著差异。术后四次评估中,2组疼痛未得到充分缓解(即VAS评分>30mm且OVRS>1)的患者数量显著高于5组和10组(P<0.01)。10组有16例患者镇静评分>1,而2组和5组各有10例。此外,10组有19例患者出现瘙痒,2组和5组各有12例。这些差异无统计学意义。三组恶心情况无显著差异。

结论

我们得出结论,0.1%布比卡因与5μg/ml芬太尼用于胸段硬膜外镇痛在开胸术后镇痛效果与副作用之间提供了最佳平衡。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验