Hertig Alexandre, Rondeau Eric
Department of Nephrology A and INSERM U489, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France.
J Am Soc Nephrol. 2004 Apr;15(4):844-53. doi: 10.1097/01.asn.0000115400.52705.83.
In the past decade, numerous experimental studies of genetically engineered mice have confirmed the involvement of the coagulation/fibrinolysis system during glomerular inflammation and repair, revealing many unexpected biologic effects far beyond fibrin formation and clearance. Resident glomerular cells and macrophages seem to act in concert to ensure the long-term consolidation of local injury and progression toward glomerulosclerosis. These recent advances will probably pave the way to a new therapeutic approach to renal diseases. However, the balance governing glomerular permeability is very delicate, and many issues will have to be dealt with before targeting this system.
在过去十年中，对基因工程小鼠的大量实验研究证实了凝血/纤溶系统在肾小球炎症和修复过程中的参与，揭示了许多远远超出纤维蛋白形成和清除的意外生物学效应。肾小球固有细胞和巨噬细胞似乎协同作用，以确保局部损伤的长期巩固和向肾小球硬化的进展。这些最新进展可能会为肾脏疾病的新治疗方法铺平道路。然而，控制肾小球通透性的平衡非常微妙，在针对该系统之前还必须处理许多问题。
