Mehta R R, Hart G, Das Gupta T K
Specialized Center for Cancer Research and Education, University of Illinois, Chicago 60612.
Anticancer Res. 1992 Jul-Aug;12(4):1311-4.
The influence of host age on estrogen (ER) and progesterone (PR) receptor status was studied in 603 tumors obtained from women with confirmed diagnosis of breast carcinoma. Both ER and PR analysis were performed in our own laboratory using standard techniques. Tumors were classified as positive if minimum receptor contents were greater than 10 fmol/mg cytosol protein and if dissociation constants were 1-9 x 10(-10) M or lower. Data from our study indicate that the incidence of receptor negative (ER-PR-) tumors was higher in women from 21 to 40 years of age than in women from 41 to 60 years of age. In women over 60 years of age, the incidence of ER+PR+ tumors was higher than in women under 40 years of age. Interestingly, women from 51 to 60 years of age had a significantly lower incidence (P less than 0.06, 0.0001) of ER+PR+ but higher incidence (P less than 0.01) of ER-PR- tumors than women 41-50 or greater than 60 years of age. Analysis of steroid receptor distribution in relation to host age and obesity showed a definite tendency: in obese women over 60 years of age, frequency of ER+PR+ was significantly greater than in non-obese women of similar age groups. This altered ER and PR distribution in tumors is probably a result of difference in the hormonal milieu associated with host menopausal status and obesity.
在603例确诊为乳腺癌的女性患者的肿瘤样本中，研究了宿主年龄对雌激素（ER）和孕激素（PR）受体状态的影响。ER和PR分析均在我们自己的实验室中采用标准技术进行。如果最低受体含量大于10 fmol/mg胞浆蛋白且解离常数为1 - 9×10⁻¹⁰ M或更低，则肿瘤被分类为阳性。我们的研究数据表明，21至40岁女性中受体阴性（ER⁻PR⁻）肿瘤的发生率高于41至60岁的女性。在60岁以上的女性中，ER⁺PR⁺肿瘤的发生率高于40岁以下的女性。有趣的是，51至60岁的女性与41至50岁或60岁以上的女性相比，ER⁺PR⁺肿瘤的发生率显著更低（P＜0.06，0.0001），但ER⁻PR⁻肿瘤的发生率更高（P＜0.01）。分析类固醇受体分布与宿主年龄和肥胖的关系显示出一种明确的趋势：在60岁以上的肥胖女性中，ER⁺PR⁺的频率显著高于同龄非肥胖女性。肿瘤中这种ER和PR分布的改变可能是与宿主绝经状态和肥胖相关的激素环境差异的结果。
