[雌激素受体/孕激素受体比值作为乳腺癌中雌激素受体转录活性的指标]
[The estrogen receptor/progesterone receptor quotient as an index of the transcriptional activity of estrogen receptors in breast cancer].
作者信息
Navarro M A, Díez Gibert O, Fernández-Montolí M E, Rosel P, Bonnin M R
机构信息
Sección de Hormonas, Ciutat Sanitària i Universitària de Bellvitge, L'Hospitalet de Llobregat, Barcelona.
出版信息
Med Clin (Barc). 1995 May 13;104(18):681-2.
BACKGROUND
The aim of this study was to determine whether the induction of progesterone receptors (PR) for estrogen receptors (ER) in variable in breast cancer, whether it differs among pre and post menopausal women and whether the ER/PR quotient may be an index of tumoral biology.
METHODS
The ER and PR content was determined by enzyme immunoassay in 814 breast tumors and the ER/PR quotient was calculated in the ER+PR+ tumors (n = 395).
RESULTS
ER/PR values < 1 were more frequent in premenopausal women (66%) than in post menopausal women (38%). No influence was observed with regard to age.
CONCLUSIONS
The highest ER/PR values were found in post menopausal women indicating decreased estrogen receptor transcriptional activity in this subgroup contrary to that found in premenopausal women.
背景
本研究的目的是确定乳腺癌中雌激素受体（ER）诱导的孕激素受体（PR）是否可变，绝经前后女性之间是否存在差异，以及ER/PR比值是否可能是肿瘤生物学指标。
方法
采用酶免疫分析法测定814例乳腺肿瘤中的ER和PR含量，并计算ER+PR+肿瘤（n = 395）中的ER/PR比值。
结果
绝经前女性中ER/PR值<1的情况（66%）比绝经后女性（38%）更常见。未观察到年龄的影响。
结论
绝经后女性的ER/PR值最高，表明该亚组中雌激素受体转录活性降低，这与绝经前女性相反。
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