Sunesen Morten, Changeux Jean-Pierre
Laboratoire de Recepteurs et Cognition, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France.
J Neurocytol. 2003 Jun-Sep;32(5-8):677-84. doi: 10.1023/B:NEUR.0000020616.53664.80.
The neuromuscular junction is a particular advantageous synapse to investigate the molecular processes engaged in synaptogenesis. Both the motor nerve and the muscle cell contribute to the patterned distribution of a definite set of membrane proteins into two distinct regions, a sub-synaptic end plate zone and an extra-synaptic region. Accordingly, the transcription of acetylcholine receptors is highly compartmentalized being much higher in the sub-synaptic the in the extra-synaptic region. In this review, we focus on the signaling pathways and the gene expression mechanisms that mediate the enhanced transcription in the sub-synaptic region and the silencing of transcription in extra-synaptic regions.
神经肌肉接头是研究突触发生过程中分子机制的一个特别有利的突触。运动神经和肌肉细胞都有助于将一组特定的膜蛋白有规律地分布到两个不同的区域，即突触下终板区和突触外区域。因此，乙酰胆碱受体的转录高度分区化，在突触下区域比在突触外区域高得多。在这篇综述中，我们重点关注介导突触下区域转录增强和突触外区域转录沉默的信号通路和基因表达机制。
