Kato T, Yakushiji M, Nishimura H, Terashima Y, Sasaki H, Yamabe T, Yajima A, Fujimoto S, Hashimoto M, Nishiya I
Dept. of Obstetrics and Gynecology, Kurume University School of Medicine, Japan.
Gan To Kagaku Ryoho. 1992 Aug;19(9):1285-93.
A phase III study of DWA2114R for ovarian cancer was carried out in CAP regimen by a cooperative study group consisting of 42 institutions. The response rate of 31 cases for DWA2114R regimen was 38.7% and out of 30 cases for CDDP regimen 46.7%. No significant differences were observed between the two regimens in efficacy, adverse reactions, and abnormalities in laboratory findings except for red blood cell and creatinine clearance, but the incidence of thrombocytopenia was likely to be lower in DWA2114R than in CDDP regimen. Since the DWA2114R regimen did not need hydration, or require diuretics, DWA2114R is more useful in the treatment of ovarian cancer than cisplatin.
