Bothorel B, Heller A, Grosshans E, Candas V
CNRS-INRS, Laboratoire de Physiologie et de Psychologie Environnementales, Strasbourg, France.
Arch Dermatol Res. 1992;284(3):135-40. doi: 10.1007/BF00372705.
To compare the thermoregulatory responses of normal subjects and patients with atopic dermatitis, the effect of exercise under moderate heat stress was examined in two groups of subjects. Each group of eight subjects (controls or clinical atopics) underwent a 90-min experiment after being equipped with probes for measurement of core and skin temperatures, heart rate and overall and local sweating rates. Sweat surface tension was determined from sweat collection made at the end of the session. The experimental procedure was as follows: 30 min rest at thermoneutrality, 30 min cycling at 90 W at 36 degrees C, followed by 30 min recovery sitting at rest at 36 degrees C on the cycloergometer. None of the registered variables differed significantly between the normal and atopic subjects except for variations in mean skin temperature, core-to-skin temperature difference and sweat surface tension. Since local sweating on non-affected skin under a controlled thermal clamp was not altered by atopy, it can be concluded that the thermoregulatory modifications under heat stress is of vasomotor origin, the benefit of which, in terms of heat dissipation capacity, remains uncertain. There may be alterations in the constituents of sweat, but not in its excretion rate. Local, rather than central, factors are probably involved in this qualitative change, which remains to be investigated.
为比较正常受试者和特应性皮炎患者的体温调节反应，在两组受试者中研究了中度热应激下运动的影响。每组8名受试者（对照组或临床特应性皮炎患者）在配备了用于测量核心体温、皮肤温度、心率以及全身和局部出汗率的探头后，进行了一项90分钟的实验。在实验结束时通过收集汗液来测定汗液表面张力。实验步骤如下：在热中性条件下休息30分钟，在36摄氏度下以90瓦功率进行30分钟的骑行，然后在36摄氏度下在测力计上坐着休息30分钟进行恢复。除了平均皮肤温度、核心体温与皮肤温度差值以及汗液表面张力存在差异外，正常受试者和特应性皮炎受试者之间的所有记录变量均无显著差异。由于在受控热钳夹下未受影响皮肤的局部出汗不受特应性的影响，因此可以得出结论，热应激下的体温调节改变源于血管运动，就散热能力而言，其益处仍不确定。汗液成分可能存在改变，但排泄率未变。这种质性变化可能涉及局部而非中枢因素，仍有待研究。
