Parkkinen M U, Kiistala R, Kiistala U
Faculty of Pharmacy, University of Kuopio, Finland.
Br J Dermatol. 1992 Apr;126(4):346-50. doi: 10.1111/j.1365-2133.1992.tb00676.x.
The local sweating response to thermal stress (mean ambient temperature 33 degrees C) was assessed under resting conditions on the non-eczematous back skin of 26 young men with atopic dermatitis (AD) and in 22 non-atopic controls with other dermatoses. The baseline (transepidermal) water loss was separately determined at room temperature (mean 23.6 degrees C) to calculate the pure sweat loss. A gravimetric collecting method was used for the measurements at 40, 60 and 80 min. In the heated room the sweat loss in AD patients was significantly lower at all time intervals. The cumulative sweat loss was 50-60% lower in AD patients than in the controls (P less than 0.02). Subjects with dry AD skin had a lower sweat loss than subjects with normal-looking skin. Compared with controls the sweat loss in AD patients was lowest at 40 min, suggesting a retarded sweating response. Half of the patients with AD and half of the controls had active participation in sports, and showed a greater sweat loss compared to the non-sporting subjects in the same group.
在静息条件下，对26名患有特应性皮炎（AD）的年轻男性非湿疹性背部皮肤以及22名患有其他皮肤病的非特应性对照者，评估其对热应激（平均环境温度33摄氏度）的局部出汗反应。在室温（平均23.6摄氏度）下分别测定基线（经表皮）水分流失，以计算纯出汗量。采用重量收集法在40、60和80分钟时进行测量。在加热房间里，AD患者在所有时间间隔的出汗量均显著较低。AD患者的累积出汗量比对照组低50 - 60%（P < 0.02）。皮肤干燥的AD患者出汗量低于外观正常皮肤的患者。与对照组相比，AD患者在40分钟时出汗量最低，表明出汗反应延迟。一半的AD患者和一半的对照者积极参与运动，与同组非运动受试者相比，出汗量更大。
