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应用于细菌致病性的分子科赫法则——15年后的个人回忆

Molecular Koch's postulates applied to bacterial pathogenicity--a personal recollection 15 years later.

作者信息

Falkow Stanley

机构信息

Stanford University School of Medicine, Stanford, California 94305-5124, USA.

出版信息

Nat Rev Microbiol. 2004 Jan;2(1):67-72. doi: 10.1038/nrmicro799.

DOI:10.1038/nrmicro799
PMID:15035010
Abstract

Koch's postulates were derived from Robert Koch's work on infectious diseases, such as anthrax and tuberculosis, which still engage us to this day. These guidelines were an attempt to establish a standard for identifying the specific causation of an infectious disease and to convince sceptics that microorganisms could cause disease. They were also established to encourage an increasing number of novice microbiologists to use more rigorous criteria before claiming a causal relationship between a microorganism and a disease.

摘要

科赫法则源自罗伯特·科赫对炭疽和结核病等传染病的研究,这些研究至今仍与我们息息相关。这些准则旨在确立一种标准,以确定传染病的具体病因,并让怀疑论者相信微生物可引发疾病。其确立的目的还在于鼓励越来越多的微生物学新手在宣称微生物与疾病之间存在因果关系之前,采用更为严谨的标准。

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