宫颈上皮内瘤变中的细胞介导免疫

Cell-mediated immunity in cervical intraepithelial neoplasia.

作者信息

Park T K, Kim S N, Choi D H, Lee C H

机构信息

Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Asia Oceania J Obstet Gynaecol. 1992 Jun;18(2):171-5. doi: 10.1111/j.1447-0756.1992.tb00318.x.

DOI:10.1111/j.1447-0756.1992.tb00318.x

PMID:1503541

Abstract

Various immune parameters, i.e., peripheral T and B cell distribution, T cell subpopulation, interleukin 2 (IL-2) activity and in vitro lymphocyte responses to phytohemagglutinin (PHA) and concanavalin A (Con A), were investigated in 24 pretreated patients with cervical intraepithelial neoplasia (CIN) and in 35 normal controls. Of the measured parameters, lymphocyte response to PHA was significantly lower in the CIN than control group (P less than 0.05). The values of all other measured parameters were similar in both groups.

摘要

对24例经预处理的宫颈上皮内瘤变（CIN）患者和35例正常对照者的各种免疫参数进行了研究，即外周血T和B细胞分布、T细胞亚群、白细胞介素2（IL-2）活性以及体外淋巴细胞对植物血凝素（PHA）和刀豆蛋白A（Con A）的反应。在所测量的参数中，CIN组淋巴细胞对PHA的反应明显低于对照组（P<0.05）。两组中所有其他测量参数的值相似。