Hsu M M, Lin B L
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1985 Nov;18(4):224-31.
The mitogenesis of lymphocyte subpopulations in response to phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) were studied in 75 patients with nasopharyngeal carcinoma (NPC) and in 51 healthy controls. The net increments of isotope incorporation of either T cells or B cells in NPC patients with PHA, Con A or PWM stimulation were far less than those in controls, with statistical significance (p less than 0.001) respectively. However, there was no link between the mitogenesis and the clinical stage. It is concluded that it is of doubtful value to use quantitative mitogenesis in NPC patients as a prognostic indicator. A study of loco-regional immune response is suggested.
对75例鼻咽癌患者和51例健康对照者研究了淋巴细胞亚群对植物血凝素（PHA）、刀豆蛋白A（Con A）和商陆有丝分裂原（PWM）的促有丝分裂反应。鼻咽癌患者经PHA、Con A或PWM刺激后，T细胞或B细胞的同位素掺入净增量远低于对照组，差异具有统计学意义（p<0.001）。然而，促有丝分裂反应与临床分期之间无关联。结论是，将鼻咽癌患者的定量促有丝分裂反应作为预后指标的价值存疑。建议开展局部区域免疫反应研究。
