Ray Theresa L, Berkenbosch John W, Russo Pierantonio, Tobias Joseph D
Department of Child Health, The University of Missouri, Columbia, MO 65212, USA.
J Intensive Care Med. 2004 Jan-Feb;19(1):44-50. doi: 10.1177/0885066603259942.
The authors retrospectively review the clinical course and outcome of 6 pediatric patients, ranging in age from 2 to 13 years, who were treated with TPA for complex empyema. Efficacy was assessed by evaluating pleural fluid drainage for 6 hours prior to and subsequent to each dose of TPA, as well as by resolution of fever and length of hospital stay. The average volume drained for 6 hours before infusion of TPA was 22.5 mL +/- 18.4 mL, and the average volume 6 hours after TPA therapy was 141.7 mL +/- 28.3 mL, P <.0001. After initiation of TPA therapy, 5 out of 6 patients became afebrile within 48 hours. The median length of stay after initiation of TPA therapy was 6 days, with a range from 4 days to 12 days. A discussion of other current therapies for empyema, along with a comparison of these therapies to TPA regarding the costs of therapies and risk-benefit ratios, is also included.
作者回顾性分析了6例年龄在2至13岁之间、接受组织纤溶酶原激活剂（TPA）治疗复杂性脓胸的儿科患者的临床病程及预后。通过评估每次给予TPA前后6小时的胸腔积液引流量、发热消退情况及住院时间来评估疗效。输注TPA前6小时的平均引流量为22.5 mL±18.4 mL，TPA治疗后6小时的平均引流量为141.7 mL±28.3 mL，P<0.0001。开始TPA治疗后，6例患者中有5例在48小时内退热。TPA治疗开始后的中位住院时间为6天，范围为4天至12天。文中还讨论了目前治疗脓胸的其他疗法，并将这些疗法与TPA在治疗成本和风险效益比方面进行了比较。
