Loriga M, Paglietti G, Piras S, Sparatore F, Anania V, Demontis M P, Varoni M V, Fattaccio M C
Istituto di Chimica Farmaceutica e Tossicologica, Università di Sassari.
Farmaco. 1992 Mar;47(3):287-303.
Several compounds possessing imidazo[4,5-b]pyridine and benzimidazole structure bearing substituents in position 2 were prepared in order to evaluate an anti-ulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole. Among sixteen compounds taken as representatives of the synthetised series only one (3d) showed a good activity by i.m. administration at 50 mg/kg, while by oral administration of 100 mg/kg a certain number was active and in some cases this activity was quite superior to that of omeprazole.
