Hornum Lars, Markholst Helle
Type 1 Pharmacology, Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark.
Curr Diab Rep. 2004 Apr;4(2):135-42. doi: 10.1007/s11892-004-0069-6.
Type 1 diabetes is an autoimmune disease with a complex polygenic inheritance. Until recently, only three susceptibility genes had been reproducibly identified, namely HLA, INS-VNTR, and CTLA4. During the past 7 years, a number of new putative susceptibility genes have been isolated from both human and animal models of the disease. We present eight genes implicated in type 1 diabetes etiology and discuss them in relation to the pathogenesis of the disease: VDR, IL6, IL12B, AIRE, FOXP3, B2m, Cblb, and Lyp/Ian4l1.
