Cyclohepta[b]pyran derivatives with platelet antiaggregating and other activities.
作者信息
Bargagna A, Longobardi M, Mariani E, Schenone P, Rossi F, D'Amico M, Falzarano C
机构信息
Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
出版信息
Farmaco. 1992 Mar;47(3):345-55.
PMID:1503598
Abstract
The synthesis of some N,N-disubstituted 4-amino-6,7,8,9-tetrahydro-3-phenylcyclohepta[b]pyran-2(5H)-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecycloheptanones, followed by dehydrochlorination of the primary adducts with DBN, is described. Some compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak local anesthetic, antiinflammatory and analgesic activities in mice and rats.
摘要
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