分光光度法测定剂型中的地尔硫䓬。
Spectrophotometric determination of diltiazem in dosage forms.
作者信息
Zivanov-Stakić D, Agbaba D, Vladimirov S, Cirić L J
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
出版信息
Farmaco. 1992 Mar;47(3):393-6.
PMID:1503602
Abstract
A simple and reproducible method for determination of diltiazem in bulk and in dosage forms is presented. The method is based on formation of hydroxamic acid, which reacts with iron (III), forming a complex with a maximum absorption at 525 nm. Assay procedure for diltiazem dosage form requires thin-layer chromatographic separation prior to colorimetric analysis.
摘要
本文介绍了一种测定原料药和制剂中地尔硫䓬的简单且可重复的方法。该方法基于异羟肟酸的形成，异羟肟酸与铁（III）反应，形成在525nm处有最大吸收的络合物。地尔硫䓬制剂的测定程序需要在比色分析之前进行薄层色谱分离。
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