McCulloch Richard
Wellcome Centre for Molecular Parasitology, University of Glasgow, Anderson College, 56 Dumbarton Road, Glasgow, G11 6NU, UK.
Trends Parasitol. 2004 Mar;20(3):117-21. doi: 10.1016/j.pt.2003.12.004.
Antigenic variation is central to the success of African trypanosomes and other eukaryotic, bacterial and viral pathogens. Our understanding of the control and execution of this immune evasion strategy in trypanosomes is incomplete, despite the molecular basis of antigenic variation being first described over 20 years ago. Recent research progress in this field is highlighted here and some of the unresolved questions raised.
抗原变异是非洲锥虫以及其他真核、细菌和病毒病原体成功感染的关键因素。尽管抗原变异的分子基础早在20多年前就已被描述，但我们对锥虫中这种免疫逃避策略的控制和实施机制仍了解不足。本文重点介绍了该领域的最新研究进展，并提出了一些尚未解决的问题。
