Thomas Serge L Y, Lew Virgilio L
Centre National de la Recherche Scientifique, UPR 9042, Station Biologique, Place G Teissier, BP 74, 29682 Roscoff cedex, France.
Trends Parasitol. 2004 Mar;20(3):122-5. doi: 10.1016/j.pt.2004.01.003.
Invasion of red blood cells by malaria parasites leads to a huge increase in solute traffic across the membrane of a normally tight cell. Recent electrophysiological investigations strongly support earlier evidence from transport and pharmacological studies that the permeability pathway, which the parasite induces in the host cell membrane, is an anion-selective channel. This article analyzes the evidence and controversies concerning the nature of this channel, surveys the main open questions and suggests directions for future research in this area.
疟原虫侵入红细胞会导致溶质通过一个通常紧密的细胞的膜的流量大幅增加。最近的电生理学研究有力地支持了早期运输和药理学研究的证据，即寄生虫在宿主细胞膜中诱导产生的通透性途径是一个阴离子选择性通道。本文分析了有关该通道性质的证据和争议，审视了主要的未解决问题，并提出了该领域未来研究的方向。
