Merckx Anaïs, Bouyer Guillaume, Thomas Serge L Y, Langsley Gordon, Egée Stéphane
Institut Cochin, INSERM U567, Université Paris Descartes, CNRS (UMR 8104), Paris, France.
Trends Parasitol. 2009 Mar;25(3):139-44. doi: 10.1016/j.pt.2008.12.005. Epub 2009 Feb 4.
By replicating within red blood cells, malaria parasites are largely hidden from immune recognition; however, in the cells, nutrients are limiting and hazardous metabolic end products can rapidly accumulate. Therefore, to survive within erythrocytes, parasites alter the permeability of the host plasma membrane, either by upregulating existing transporters or by creating new permeation pathways. Recent electrophysiological studies of Plasmodium-infected erythrocytes have demonstrated that membrane permeability is mediated by transmembrane transport through ion channels in the infected erythrocyte. This article discusses the evidence and controversies concerning the nature of these channels and surveys the potential role of phosphorylation in activating anion channels that could be important in developing novel strategies for future malarial chemotherapies.
通过在红细胞内复制，疟原虫在很大程度上躲避了免疫识别；然而，在细胞内，营养物质有限，有害的代谢终产物会迅速积累。因此，为了在红细胞内存活，寄生虫会通过上调现有的转运蛋白或创建新的渗透途径来改变宿主质膜的通透性。最近对感染疟原虫的红细胞的电生理学研究表明，膜通透性是由感染红细胞中的离子通道介导的跨膜运输实现的。本文讨论了有关这些通道性质的证据和争议，并探讨了磷酸化在激活阴离子通道中的潜在作用，这可能对开发未来疟疾化疗的新策略很重要。
