Noël Wim, Raes Geert, Hassanzadeh Ghassabeh Gholamreza, De Baetselier Patrick, Beschin Alain
Department of Cellular and Molecular Interactions, Flemish Interuniversity Institute for Biotechnology, Free University of Brussels (VIB-VUB), Building E, Floor 8, Pleinlaan 2, B-1050 Brussels, Belgium.
Trends Parasitol. 2004 Mar;20(3):126-33. doi: 10.1016/j.pt.2004.01.004.
Depending on the cytokine environment, macrophages can differentiate into distinct subsets that perform specific immunological roles. In this regard, the functions of macrophages activated by interferon gamma, referred to as classically activated macrophages, have been extensively documented, particularly during immune responses to infection. Recently, it was recognized that macrophages exposed to cytokines generated by T helper cell type 2 (Th2) cells exert an alternative activation program. However, the nature and functions of alternatively activated macrophages are ill defined. Evidence for the presence of alternatively activated macrophages and their possible influence in the outcome of several parasite diseases are discussed here.
根据细胞因子环境，巨噬细胞可分化为具有特定免疫功能的不同亚群。在这方面，被干扰素γ激活的巨噬细胞（即经典激活的巨噬细胞）的功能已得到广泛记录，尤其是在对感染的免疫反应过程中。最近，人们认识到暴露于2型辅助性T细胞（Th2）产生的细胞因子中的巨噬细胞会启动一种替代性激活程序。然而，替代性激活的巨噬细胞的性质和功能尚不清楚。本文将讨论替代性激活的巨噬细胞的存在证据及其对几种寄生虫病结局可能产生的影响。
